منابع مشابه
Microtubule catastrophe and rescue.
Microtubules are long cylindrical polymers composed of tubulin subunits. In cells, microtubules play an essential role in architecture and motility. For example, microtubules give shape to cells, serve as intracellular transport tracks, and act as key elements in important cellular structures such as axonemes and mitotic spindles. To accomplish these varied functions, networks of microtubules i...
متن کاملMicrotubule Assembly: Catastrophe Factors to the Rescue
Two new studies have shown how regulation of microtubule dynamics by members of the kinesin superfamily may guard against errors in spindle assembly and chromosome segregation.
متن کاملThe mechanisms of microtubule catastrophe and rescue: implications from analysis of a dimer-scale computational model
Microtubule (MT) dynamic instability is fundamental to many cell functions, but its mechanism remains poorly understood, in part because it is difficult to gain information about the dimer-scale events at the MT tip. To address this issue, we used a dimer-scale computational model of MT assembly that is consistent with tubulin structure and biochemistry, displays dynamic instability, and covers...
متن کاملMicrotubule catastrophe from protofilament dynamics.
The disappearance of the guanosine triphosphate- (GTP) tubulin cap is widely believed to be the forerunner event for the growth-shrinkage transition ("catastrophe") in microtubule filaments in eukaryotic cells. We study a discrete version of a stochastic model of the GTP cap dynamics, originally proposed by Flyvbjerg, Holy, and Leibler [Phys. Rev. Lett. 73, 2372 (1994)]. Our model includes both...
متن کاملDynamics of Microtubule Growth and Catastrophe
We investigate a simple dynamical model of a microtubule that evolves by attachment of guanosine triphosphate (GTP) tubulin to its end, irreversible conversion of GTP to guanosine diphosphate (GDP) tubulin by hydrolysis, and detachment of GDP at the end of a microtubule. As a function of rates of these processes, the microtubule can grow steadily or its length can fluctuate wildly. In the regim...
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ژورنال
عنوان ژورنال: Current Opinion in Cell Biology
سال: 2013
ISSN: 0955-0674
DOI: 10.1016/j.ceb.2012.09.006